There's a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to lower afferent discomfort transmission and create analgesia. Hence, medicine like clonidine that focus on alpha-two receptors can influence the transmission of discomfort. This information is not a substitute for https://shahrukhn516hyp2.wikitidings.com/user