Vegetation are historically a supply of analgesic alkaloids, While their pharmacological characterization is usually constrained. Between these pure analgesic molecules, conolidine, found in the bark with the tropical flowering shrub Tabernaemontana divaricata We demonstrated that, in contrast to classical opioid receptors, ACKR3 does not trigger classical G protein signaling https://www.proleviate.com/post/what-are-the-side-effects-of-conolidine